While I generally recommend WebEx and GoToMeeting for Remote Demos, largely due to their imbedded annotations capabilities, there is now a viable option for Lync and other packages that lack annotation capabilities (the ability to draw over the live application that is being demonstrated): ZoomIt provides some of these tools, plus the ability to zoom to focus on a specific area of the screen.
I’ve seen it in action and the annotation tools are reasonably good, although not as rich as in WebEx or GoToMeeting; zooming can also be helpful, but be careful not to execute a zoom too fast (or you will have people reaching from the Dramamine!).